FACTS ABOUT NR1-SITE REVEALED

Working with this approach, Kalbaugh et al. assigned affinity and efficacy roles to positions while in the LBDs of the NR1 and NR2A NMDAR subunits. In situ mutation of residues in immediate contact with bound ligand affected equally efficacy and affinity, though positions that stabilize the shut cleft conformation and not using a direct ligand inte